Lesson Plan – Critical Appraisal – The HALT-IT trial

Picture the scene…

A patient is brought into the Resus Room with haematemesis. You’ve started a blood transfusion and wonder if giving TXA (tranexamic acid) may help…

Learning Objective

To critically appraise the HALT-IT study

RCEM Curriculum


Task 1 – Read the Paper

Task 2 – Listen

Task 3 – Discuss

Task 4 – Summary

Task 5 – Reflect


  1. 1
    Roberts I, Shakur-Still H, Afolabi A, et al. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. The Lancet 2020; : 1927–36.